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Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Enhancement of hematopoietic stem cell (HSC) homing and engraftment is clinically critical, especially for cord blood (CB) hematopoietic cell transplantation. Here we report that specific HDAC5 inhibition highly upregulates CXCR4 surface expression in human CB HSCs and progenitor cells (HPCs). This...

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Detalles Bibliográficos
Autores principales:	Huang, Xinxin, Guo, Bin, Liu, Sheng, Wan, Jun, Broxmeyer, Hal E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048146/ https://www.ncbi.nlm.nih.gov/pubmed/30013077 http://dx.doi.org/10.1038/s41467-018-05178-5

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