Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer

Bax is a key molecule in mitochondria-apoptosis pathway, however it is not always an efficient apoptosis inducer in chemotherapeutic agents-treated cancer cells. Here, we found that specific inhibition of AURKA by MLN8237-induced calpain-mediated Bax cleavage at N-terminal 33th asparagine (c-Bax) to...

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Detalles Bibliográficos
Autores principales: Hou, Daisen, Che, Zhihui, Chen, Ping, Zhang, Wenli, Chu, Yiwei, Yang, Dongqin, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048174/
https://www.ncbi.nlm.nih.gov/pubmed/30013101
http://dx.doi.org/10.1038/s41419-018-0823-3

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