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The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese
Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on MALAT1 gene in a Chinese population of children with congenit...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048208/ https://www.ncbi.nlm.nih.gov/pubmed/29559566 http://dx.doi.org/10.1042/BSR20171381 |
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author | Li, Qian Zhu, Wenying Zhang, Bei Wu, Yiping Yan, Sen Yuan, Yufeng Zhang, Haiyan Li, Jie Sun, Kai Wang, Hua Yu, Tingting |
author_facet | Li, Qian Zhu, Wenying Zhang, Bei Wu, Yiping Yan, Sen Yuan, Yufeng Zhang, Haiyan Li, Jie Sun, Kai Wang, Hua Yu, Tingting |
author_sort | Li, Qian |
collection | PubMed |
description | Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on MALAT1 gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP’s function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with lower risk of CHD (odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.59–0.92, P=0.014) in additive model. Functional investigation indicated that G allele of rs619586 could trigger higher expression of MALAT1. We demonstrated that the functional MALAT1 polymorphism rs619586 A>G was significantly associated with CHD susceptibility in Chinese population, potentially via regulating MALAT1 expression. |
format | Online Article Text |
id | pubmed-6048208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60482082018-07-23 The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese Li, Qian Zhu, Wenying Zhang, Bei Wu, Yiping Yan, Sen Yuan, Yufeng Zhang, Haiyan Li, Jie Sun, Kai Wang, Hua Yu, Tingting Biosci Rep Research Articles Many long non-coding RNAs (lncRNAs), including lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), are involved in various cardiac diseases. We evaluated the effects of tag single nucleotide polymorphisms (tag-SNPs) on MALAT1 gene in a Chinese population of children with congenital heart disease (CHD). In the present study, 713 CHD patients and 730 gender- and age-matched children without CHD were genotyped for MALAT1 tag-SNPs rs11227209, rs619586, and rs3200401. Further investigation of SNP’s function was performed by luciferase assay. Statistical analyses, including uni- and multivariate logistic regression were performed to quantitate the association between these tag SNPs and CHD. We discovered that MALAT1 rs619586 GG allele was significantly associated with lower risk of CHD (odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.59–0.92, P=0.014) in additive model. Functional investigation indicated that G allele of rs619586 could trigger higher expression of MALAT1. We demonstrated that the functional MALAT1 polymorphism rs619586 A>G was significantly associated with CHD susceptibility in Chinese population, potentially via regulating MALAT1 expression. Portland Press Ltd. 2018-05-22 /pmc/articles/PMC6048208/ /pubmed/29559566 http://dx.doi.org/10.1042/BSR20171381 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Li, Qian Zhu, Wenying Zhang, Bei Wu, Yiping Yan, Sen Yuan, Yufeng Zhang, Haiyan Li, Jie Sun, Kai Wang, Hua Yu, Tingting The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title | The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title_full | The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title_fullStr | The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title_full_unstemmed | The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title_short | The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese |
title_sort | malat1 gene polymorphism and its relationship with the onset of congenital heart disease in chinese |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048208/ https://www.ncbi.nlm.nih.gov/pubmed/29559566 http://dx.doi.org/10.1042/BSR20171381 |
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