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Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering

Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing, motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due to injury, pathology, and aging. Annulus fibrosus (AF), the structural and functional integrity of which is criticall...

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Autores principales: Chu, Genglei, Shi, Chen, Wang, Huan, Zhang, Weidong, Yang, Huilin, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048238/
https://www.ncbi.nlm.nih.gov/pubmed/30042942
http://dx.doi.org/10.3389/fbioe.2018.00090
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author Chu, Genglei
Shi, Chen
Wang, Huan
Zhang, Weidong
Yang, Huilin
Li, Bin
author_facet Chu, Genglei
Shi, Chen
Wang, Huan
Zhang, Weidong
Yang, Huilin
Li, Bin
author_sort Chu, Genglei
collection PubMed
description Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing, motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due to injury, pathology, and aging. Annulus fibrosus (AF), the structural and functional integrity of which is critically essential to confine nucleus pulpous (NP) and maintain physiological intradiscal pressure under mechanical loading, plays a critical role in the biomechanical properties of IVD. AF degeneration commonly results in substantial deterioration of IVD. During this process, the biomechanical properties of AF and the balance between anabolism and catabolism in IVD are progressively disrupted, leading to chronic back pain, and even disability of individuals. Therefore, repairing and regenerating AF are effective treatments to degeneration-associated pains. However, they remain highly challenging due to the complexity of natural AF tissue in the aspects of cell phenotype, biochemical composition, microstructure, and mechanical properties. Tissue engineering (TE), by combining biological science and materials engineering, shed lights on AF regeneration. In this article, we review recent advances in the pro-anabolic approaches in the form of cell delivery, bioactive factors delivery, gene therapy, and TE strategies for achieving AF regeneration.
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spelling pubmed-60482382018-07-24 Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering Chu, Genglei Shi, Chen Wang, Huan Zhang, Weidong Yang, Huilin Li, Bin Front Bioeng Biotechnol Bioengineering and Biotechnology Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing, motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due to injury, pathology, and aging. Annulus fibrosus (AF), the structural and functional integrity of which is critically essential to confine nucleus pulpous (NP) and maintain physiological intradiscal pressure under mechanical loading, plays a critical role in the biomechanical properties of IVD. AF degeneration commonly results in substantial deterioration of IVD. During this process, the biomechanical properties of AF and the balance between anabolism and catabolism in IVD are progressively disrupted, leading to chronic back pain, and even disability of individuals. Therefore, repairing and regenerating AF are effective treatments to degeneration-associated pains. However, they remain highly challenging due to the complexity of natural AF tissue in the aspects of cell phenotype, biochemical composition, microstructure, and mechanical properties. Tissue engineering (TE), by combining biological science and materials engineering, shed lights on AF regeneration. In this article, we review recent advances in the pro-anabolic approaches in the form of cell delivery, bioactive factors delivery, gene therapy, and TE strategies for achieving AF regeneration. Frontiers Media S.A. 2018-07-10 /pmc/articles/PMC6048238/ /pubmed/30042942 http://dx.doi.org/10.3389/fbioe.2018.00090 Text en Copyright © 2018 Chu, Shi, Wang, Zhang, Yang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Chu, Genglei
Shi, Chen
Wang, Huan
Zhang, Weidong
Yang, Huilin
Li, Bin
Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title_full Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title_fullStr Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title_full_unstemmed Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title_short Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
title_sort strategies for annulus fibrosus regeneration: from biological therapies to tissue engineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048238/
https://www.ncbi.nlm.nih.gov/pubmed/30042942
http://dx.doi.org/10.3389/fbioe.2018.00090
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