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Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

Introduction: Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation of the mitochondrial fission mediator dynamin-related protein 1 (Drp1) contrib...

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Detalles Bibliográficos
Autores principales:	Tian, Lian, Potus, Francois, Wu, Danchen, Dasgupta, Asish, Chen, Kuang-Hueih, Mewburn, Jeffrey, Lima, Patricia, Archer, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048272/ https://www.ncbi.nlm.nih.gov/pubmed/30042687 http://dx.doi.org/10.3389/fphys.2018.00828

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