MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas

Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGM...

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Autores principales: ABE, Hideaki, NATSUMEDA, Manabu, KANEMARU, Yu, WATANABE, Jun, TSUKAMOTO, Yoshihiro, OKADA, Masayasu, YOSHIMURA, Junichi, OISHI, Makoto, FUJII, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048353/
https://www.ncbi.nlm.nih.gov/pubmed/29848907
http://dx.doi.org/10.2176/nmc.ra.2018-0044
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author ABE, Hideaki
NATSUMEDA, Manabu
KANEMARU, Yu
WATANABE, Jun
TSUKAMOTO, Yoshihiro
OKADA, Masayasu
YOSHIMURA, Junichi
OISHI, Makoto
FUJII, Yukihiko
author_facet ABE, Hideaki
NATSUMEDA, Manabu
KANEMARU, Yu
WATANABE, Jun
TSUKAMOTO, Yoshihiro
OKADA, Masayasu
YOSHIMURA, Junichi
OISHI, Makoto
FUJII, Yukihiko
author_sort ABE, Hideaki
collection PubMed
description Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGMT) promoter frequently lacks methylation in DMGs. This review compares the epigenetic changes brought about by histone mutations to those by isocitrate dehydrogenase-mutant gliomas, which frequently have methylated MGMT promoters and are known to be sensitive to temozolomide.
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spelling pubmed-60483532018-07-18 MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas ABE, Hideaki NATSUMEDA, Manabu KANEMARU, Yu WATANABE, Jun TSUKAMOTO, Yoshihiro OKADA, Masayasu YOSHIMURA, Junichi OISHI, Makoto FUJII, Yukihiko Neurol Med Chir (Tokyo) Review Article Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O(6)-methylguanine-DNA methyltransferase (MGMT) promoter frequently lacks methylation in DMGs. This review compares the epigenetic changes brought about by histone mutations to those by isocitrate dehydrogenase-mutant gliomas, which frequently have methylated MGMT promoters and are known to be sensitive to temozolomide. The Japan Neurosurgical Society 2018-07 2018-05-31 /pmc/articles/PMC6048353/ /pubmed/29848907 http://dx.doi.org/10.2176/nmc.ra.2018-0044 Text en © 2018 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review Article
ABE, Hideaki
NATSUMEDA, Manabu
KANEMARU, Yu
WATANABE, Jun
TSUKAMOTO, Yoshihiro
OKADA, Masayasu
YOSHIMURA, Junichi
OISHI, Makoto
FUJII, Yukihiko
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title_full MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title_fullStr MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title_full_unstemmed MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title_short MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
title_sort mgmt expression contributes to temozolomide resistance in h3k27m-mutant diffuse midline gliomas and mgmt silencing to temozolomide sensitivity in idh-mutant gliomas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048353/
https://www.ncbi.nlm.nih.gov/pubmed/29848907
http://dx.doi.org/10.2176/nmc.ra.2018-0044
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