Cargando…
Biological Mechanisms of Cancer-Induced Depression
Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-underst...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048357/ https://www.ncbi.nlm.nih.gov/pubmed/30042700 http://dx.doi.org/10.3389/fpsyt.2018.00299 |
_version_ | 1783340097203077120 |
---|---|
author | Young, Kimberly Singh, Gurmit |
author_facet | Young, Kimberly Singh, Gurmit |
author_sort | Young, Kimberly |
collection | PubMed |
description | Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories have emerged postulating the mechanisms underlying the development of depressive disorder. Here, we review the role inflammation, a hyperactive hypothalamic-pituitary-adrenal (HPA) axis, and glutamate excitotoxicity may play in cancer-induced depression. Hopefully, novel therapeutics targeting these dysregulated pathways may be potent in ameliorating depressive symptoms in the cancer population. |
format | Online Article Text |
id | pubmed-6048357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60483572018-07-24 Biological Mechanisms of Cancer-Induced Depression Young, Kimberly Singh, Gurmit Front Psychiatry Psychiatry Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories have emerged postulating the mechanisms underlying the development of depressive disorder. Here, we review the role inflammation, a hyperactive hypothalamic-pituitary-adrenal (HPA) axis, and glutamate excitotoxicity may play in cancer-induced depression. Hopefully, novel therapeutics targeting these dysregulated pathways may be potent in ameliorating depressive symptoms in the cancer population. Frontiers Media S.A. 2018-07-10 /pmc/articles/PMC6048357/ /pubmed/30042700 http://dx.doi.org/10.3389/fpsyt.2018.00299 Text en Copyright © 2018 Young and Singh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Young, Kimberly Singh, Gurmit Biological Mechanisms of Cancer-Induced Depression |
title | Biological Mechanisms of Cancer-Induced Depression |
title_full | Biological Mechanisms of Cancer-Induced Depression |
title_fullStr | Biological Mechanisms of Cancer-Induced Depression |
title_full_unstemmed | Biological Mechanisms of Cancer-Induced Depression |
title_short | Biological Mechanisms of Cancer-Induced Depression |
title_sort | biological mechanisms of cancer-induced depression |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048357/ https://www.ncbi.nlm.nih.gov/pubmed/30042700 http://dx.doi.org/10.3389/fpsyt.2018.00299 |
work_keys_str_mv | AT youngkimberly biologicalmechanismsofcancerinduceddepression AT singhgurmit biologicalmechanismsofcancerinduceddepression |