PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. Here, w...

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Detalles Bibliográficos
Autores principales: Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco, Carroll, Thomas, Dharmalingam, Gopuraja, Wee, Keng Boon, Mellone, Marco, Pombo, Joaquim, Heide, Danijela, Guccione, Ernesto, Arribas, Joaquín, Barbosa-Morais, Nuno L., Heikenwalder, Mathias, Thomas, Gareth J., Zender, Lars, Gil, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048363/
https://www.ncbi.nlm.nih.gov/pubmed/29990503
http://dx.doi.org/10.1016/j.ccell.2018.06.007

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