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Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum
Fusarium is a diverse assemblage that includes a large number of species of considerable medical and agricultural importance. Not surprisingly, whole genome sequences for many Fusarium species have been published or are in the process of being determined, the availability of which is invaluable for...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Mycological Association
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048564/ https://www.ncbi.nlm.nih.gov/pubmed/30018870 http://dx.doi.org/10.5598/imafungus.2018.09.01.03 |
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author | Van Wyk, Stephanie Wingfield, Brenda D. De Vos, Lieschen Santana, Quentin C. Van der Merwe, Nicolaas A. Steenkamp, Emma T. |
author_facet | Van Wyk, Stephanie Wingfield, Brenda D. De Vos, Lieschen Santana, Quentin C. Van der Merwe, Nicolaas A. Steenkamp, Emma T. |
author_sort | Van Wyk, Stephanie |
collection | PubMed |
description | Fusarium is a diverse assemblage that includes a large number of species of considerable medical and agricultural importance. Not surprisingly, whole genome sequences for many Fusarium species have been published or are in the process of being determined, the availability of which is invaluable for deciphering the genetic basis of key phenotypic traits. Here we investigated the distribution, genic composition, and evolutionary history of a locus potentially determining growth rate in the pitch canker pathogen F. circinatum. We found that the genomic region underlying this locus is highly conserved amongst F. circinatum and its close relatives, except for the presence of a 12 000 base pair insertion in all of the examined isolates of F. circinatum. This insertion encodes for five genes and our phylogenetic analyses revealed that each was most likely acquired through horizontal gene transfer from polyphyletic origins. Our data further showed that this region is located in a region low in G+C content and enriched for repetitive sequences and transposable elements, which is situated near the telomere of Chromosome 3 of F. circinatum. As have been shown for other fungi, these findings thus suggest that the emergence of the unique 12 000 bp region in F. circinatum is linked to the dynamic evolutionary processes associated with subtelomeres that, in turn, have been implicated in the ecological adaptation of fungal pathogens. |
format | Online Article Text |
id | pubmed-6048564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Mycological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-60485642018-07-17 Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum Van Wyk, Stephanie Wingfield, Brenda D. De Vos, Lieschen Santana, Quentin C. Van der Merwe, Nicolaas A. Steenkamp, Emma T. IMA Fungus Article Fusarium is a diverse assemblage that includes a large number of species of considerable medical and agricultural importance. Not surprisingly, whole genome sequences for many Fusarium species have been published or are in the process of being determined, the availability of which is invaluable for deciphering the genetic basis of key phenotypic traits. Here we investigated the distribution, genic composition, and evolutionary history of a locus potentially determining growth rate in the pitch canker pathogen F. circinatum. We found that the genomic region underlying this locus is highly conserved amongst F. circinatum and its close relatives, except for the presence of a 12 000 base pair insertion in all of the examined isolates of F. circinatum. This insertion encodes for five genes and our phylogenetic analyses revealed that each was most likely acquired through horizontal gene transfer from polyphyletic origins. Our data further showed that this region is located in a region low in G+C content and enriched for repetitive sequences and transposable elements, which is situated near the telomere of Chromosome 3 of F. circinatum. As have been shown for other fungi, these findings thus suggest that the emergence of the unique 12 000 bp region in F. circinatum is linked to the dynamic evolutionary processes associated with subtelomeres that, in turn, have been implicated in the ecological adaptation of fungal pathogens. International Mycological Association 2018-02-27 2018-06 /pmc/articles/PMC6048564/ /pubmed/30018870 http://dx.doi.org/10.5598/imafungus.2018.09.01.03 Text en © 2018 International Mycological Association http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode You are free to share - to copy, distribute and transmit the work, under the following conditions: Attribution: You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). Non-commercial: You may not use this work for commercial purposes. No derivative works: You may not alter, transform, or build upon this work. For any reuse or distribution, you must make clear to others the license terms of this work, which can be found at http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode. Any of the above conditions can be waived if you get permission from the copyright holder. Nothing in this license impairs or restricts the author’s moral rights. |
spellingShingle | Article Van Wyk, Stephanie Wingfield, Brenda D. De Vos, Lieschen Santana, Quentin C. Van der Merwe, Nicolaas A. Steenkamp, Emma T. Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title | Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title_full | Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title_fullStr | Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title_full_unstemmed | Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title_short | Multiple independent origins for a subtelomeric locus associated with growth rate in Fusarium circinatum |
title_sort | multiple independent origins for a subtelomeric locus associated with growth rate in fusarium circinatum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048564/ https://www.ncbi.nlm.nih.gov/pubmed/30018870 http://dx.doi.org/10.5598/imafungus.2018.09.01.03 |
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