A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron(®) (Peginterferon alfa-2b) and Actimmune(®) (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer

BACKGROUND: Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. Interferons have both cytostatic and cytotoxic properties, while monocytes stim...

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Detalles Bibliográficos
Autores principales: Green, Daniel S., Nunes, Ana T., David-Ocampo, Virginia, Ekwede, Irene B., Houston, Nicole D., Highfill, Steven L., Khuu, Hanh, Stroncek, David F., Steinberg, Seth M., Zoon, Kathryn C., Annunziata, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048715/
https://www.ncbi.nlm.nih.gov/pubmed/30012146
http://dx.doi.org/10.1186/s12967-018-1569-5

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