β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

BACKGROUND: The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cyclase-A (GC-A) receptor. Obesity is associated with impaired NP/GC-A/cGMP signa...

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Detalles Bibliográficos
Autores principales: Tauscher, Sabine, Nakagawa, Hitoshi, Völker, Katharina, Werner, Franziska, Krebes, Lisa, Potapenko, Tamara, Doose, Sören, Birkenfeld, Andreas L., Baba, Hideo A., Kuhn, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048747/
https://www.ncbi.nlm.nih.gov/pubmed/30016962
http://dx.doi.org/10.1186/s12933-018-0747-3

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