MWASTools: an R/bioconductor package for metabolome-wide association studies

SUMMARY: MWASTools is an R package designed to provide an integrated pipeline to analyse metabonomic data in large-scale epidemiological studies. Key functionalities of our package include: quality control analysis; metabolome-wide association analysis using various models (partial correlations, gen...

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Detalles Bibliográficos
Autores principales: Rodriguez-Martinez, Andrea, Posma, Joram M, Ayala, Rafael, Neves, Ana L, Anwar, Maryam, Petretto, Enrico, Emanueli, Costanza, Gauguier, Dominique, Nicholson, Jeremy K, Dumas, Marc-Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049002/
https://www.ncbi.nlm.nih.gov/pubmed/28961702
http://dx.doi.org/10.1093/bioinformatics/btx477
Descripción
Sumario:SUMMARY: MWASTools is an R package designed to provide an integrated pipeline to analyse metabonomic data in large-scale epidemiological studies. Key functionalities of our package include: quality control analysis; metabolome-wide association analysis using various models (partial correlations, generalized linear models); visualization of statistical outcomes; metabolite assignment using statistical total correlation spectroscopy (STOCSY); and biological interpretation of metabolome-wide association studies results. AVAILABILITY AND IMPLEMENTATION: The MWASTools R package is implemented in R (version  > =3.4) and is available from Bioconductor: https://bioconductor.org/packages/MWASTools/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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