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Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination
BACKGROUND: Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached. METHODS: Serological surveys for measles and rubella can potentially measure susceptibility directly,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049004/ https://www.ncbi.nlm.nih.gov/pubmed/29562334 http://dx.doi.org/10.1093/infdis/jiy137 |
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author | Winter, Amy K Martinez, Micaela E Cutts, Felicity T Moss, William J Ferrari, Matt J McKee, Amalie Lessler, Justin Hayford, Kyla Wallinga, Jacco Metcalf, C Jess E |
author_facet | Winter, Amy K Martinez, Micaela E Cutts, Felicity T Moss, William J Ferrari, Matt J McKee, Amalie Lessler, Justin Hayford, Kyla Wallinga, Jacco Metcalf, C Jess E |
author_sort | Winter, Amy K |
collection | PubMed |
description | BACKGROUND: Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached. METHODS: Serological surveys for measles and rubella can potentially measure susceptibility directly, but their use remains rare. In this study, using simulations, we outline key subtleties in interpretation associated with the dynamic context of age-specific immunity, highlighting how the patterns of immunity predicted from disease surveillance and vaccination coverage data may be misleading. RESULTS: High-quality representative serosurveys could provide a more accurate assessment of immunity if challenges of conducting, analyzing, and interpreting them are overcome. We frame the core disease control and elimination questions that could be addressed by improved serological tools, discussing challenges and suggesting approaches to increase the feasibility and sustainability of the tool. CONCLUSIONS: Accounting for the dynamical context, serosurveys could play a key role in efforts to achieve and sustain elimination. |
format | Online Article Text |
id | pubmed-6049004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60490042018-07-20 Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination Winter, Amy K Martinez, Micaela E Cutts, Felicity T Moss, William J Ferrari, Matt J McKee, Amalie Lessler, Justin Hayford, Kyla Wallinga, Jacco Metcalf, C Jess E J Infect Dis Major Articles and Brief Reports BACKGROUND: Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached. METHODS: Serological surveys for measles and rubella can potentially measure susceptibility directly, but their use remains rare. In this study, using simulations, we outline key subtleties in interpretation associated with the dynamic context of age-specific immunity, highlighting how the patterns of immunity predicted from disease surveillance and vaccination coverage data may be misleading. RESULTS: High-quality representative serosurveys could provide a more accurate assessment of immunity if challenges of conducting, analyzing, and interpreting them are overcome. We frame the core disease control and elimination questions that could be addressed by improved serological tools, discussing challenges and suggesting approaches to increase the feasibility and sustainability of the tool. CONCLUSIONS: Accounting for the dynamical context, serosurveys could play a key role in efforts to achieve and sustain elimination. Oxford University Press 2018-08-01 2018-03-19 /pmc/articles/PMC6049004/ /pubmed/29562334 http://dx.doi.org/10.1093/infdis/jiy137 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Major Articles and Brief Reports Winter, Amy K Martinez, Micaela E Cutts, Felicity T Moss, William J Ferrari, Matt J McKee, Amalie Lessler, Justin Hayford, Kyla Wallinga, Jacco Metcalf, C Jess E Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title | Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title_full | Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title_fullStr | Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title_full_unstemmed | Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title_short | Benefits and Challenges in Using Seroprevalence Data to Inform Models for Measles and Rubella Elimination |
title_sort | benefits and challenges in using seroprevalence data to inform models for measles and rubella elimination |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049004/ https://www.ncbi.nlm.nih.gov/pubmed/29562334 http://dx.doi.org/10.1093/infdis/jiy137 |
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