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Preserved capacity for scene construction and shifts in perspective after hippocampal lesions
The hippocampus has long been recognized as important for the formation of long-term memory. Recent work has suggested that the hippocampus might also be important for certain kinds of spatial operations, as in constructing scenes, shifting perspective, or perceiving the geometry of scenes and their...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049396/ https://www.ncbi.nlm.nih.gov/pubmed/30012879 http://dx.doi.org/10.1101/lm.047340.118 |
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author | Rungratsameetaweemana, Nuttida Squire, Larry R. |
author_facet | Rungratsameetaweemana, Nuttida Squire, Larry R. |
author_sort | Rungratsameetaweemana, Nuttida |
collection | PubMed |
description | The hippocampus has long been recognized as important for the formation of long-term memory. Recent work has suggested that the hippocampus might also be important for certain kinds of spatial operations, as in constructing scenes, shifting perspective, or perceiving the geometry of scenes and their boundaries. We explored this proposal using a task similar to one used previously that related hippocampal activity to scenes and their boundaries. In our study, participants viewed scenes from above that displayed walls and towers. After viewing each scene, participants saw a scene from ground level and judged whether it was the same as or different from the scene just presented. The number of towers and walls in each scene was manipulated so that it was possible to assess how the structure of the scene affected performance. Patients with hippocampal lesions performed similarly to controls in all task conditions and had no special difficulty as a function of the layout of a scene and its boundaries. In contrast, a patient with large medial temporal lobe (MTL) lesions was impaired. Taken together, our findings suggest that the hippocampus is not needed for scene construction, shifts in perspective, or perceiving the geometry of scenes. The impairment associated with large MTL lesions may result from damage in or near parahippocampal cortex. |
format | Online Article Text |
id | pubmed-6049396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60493962019-08-01 Preserved capacity for scene construction and shifts in perspective after hippocampal lesions Rungratsameetaweemana, Nuttida Squire, Larry R. Learn Mem Research The hippocampus has long been recognized as important for the formation of long-term memory. Recent work has suggested that the hippocampus might also be important for certain kinds of spatial operations, as in constructing scenes, shifting perspective, or perceiving the geometry of scenes and their boundaries. We explored this proposal using a task similar to one used previously that related hippocampal activity to scenes and their boundaries. In our study, participants viewed scenes from above that displayed walls and towers. After viewing each scene, participants saw a scene from ground level and judged whether it was the same as or different from the scene just presented. The number of towers and walls in each scene was manipulated so that it was possible to assess how the structure of the scene affected performance. Patients with hippocampal lesions performed similarly to controls in all task conditions and had no special difficulty as a function of the layout of a scene and its boundaries. In contrast, a patient with large medial temporal lobe (MTL) lesions was impaired. Taken together, our findings suggest that the hippocampus is not needed for scene construction, shifts in perspective, or perceiving the geometry of scenes. The impairment associated with large MTL lesions may result from damage in or near parahippocampal cortex. Cold Spring Harbor Laboratory Press 2018-08 /pmc/articles/PMC6049396/ /pubmed/30012879 http://dx.doi.org/10.1101/lm.047340.118 Text en © 2018 Rungratsameetaweemana and Squire; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Rungratsameetaweemana, Nuttida Squire, Larry R. Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title | Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title_full | Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title_fullStr | Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title_full_unstemmed | Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title_short | Preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
title_sort | preserved capacity for scene construction and shifts in perspective after hippocampal lesions |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049396/ https://www.ncbi.nlm.nih.gov/pubmed/30012879 http://dx.doi.org/10.1101/lm.047340.118 |
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