Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that promotes epigenetic gene silencing, but the dynamics of its interactions with chromatin are largely unknown. Here we quantitatively measured the binding of PRC2 to chromatin in human cancer cells. Genome editing of a HaloTag in...

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Detalles Bibliográficos
Autores principales: Youmans, Daniel T., Schmidt, Jens C., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049511/
https://www.ncbi.nlm.nih.gov/pubmed/29891558
http://dx.doi.org/10.1101/gad.311936.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049511/
https://www.ncbi.nlm.nih.gov/pubmed/29891558
http://dx.doi.org/10.1101/gad.311936.118

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