Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined genetic–phosphoprot...

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Detalles Bibliográficos
Autores principales: Lanz, Michael Charles, Oberly, Susannah, Sanford, Ethan James, Sharma, Sushma, Chabes, Andrei, Smolka, Marcus Bustamante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049512/
https://www.ncbi.nlm.nih.gov/pubmed/29899143
http://dx.doi.org/10.1101/gad.308148.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049512/
https://www.ncbi.nlm.nih.gov/pubmed/29899143
http://dx.doi.org/10.1101/gad.308148.117

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