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Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling

During mammalian brain development, radial glial progenitors balance between proliferation and differentiation to generate the laminated cortical layers in a temporally precise fashion. Defects in the individual steps going into this complex organogenesis can result in cortical malformations and hum...

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Detalles Bibliográficos
Autores principales: Abdi, Khadar, Kuo, Chay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049518/
https://www.ncbi.nlm.nih.gov/pubmed/29921662
http://dx.doi.org/10.1101/gad.316711.118
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author Abdi, Khadar
Kuo, Chay T.
author_facet Abdi, Khadar
Kuo, Chay T.
author_sort Abdi, Khadar
collection PubMed
description During mammalian brain development, radial glial progenitors balance between proliferation and differentiation to generate the laminated cortical layers in a temporally precise fashion. Defects in the individual steps going into this complex organogenesis can result in cortical malformations and human nervous system disorders. In this issue of Genes & Development, Liu and colleagues (pp. 763–780) present experimental evidence that an evolutionarily conserved cellular polarity gene, Pard3 (partitioning-defective 3), controls the balance of radial glial proliferation and differentiation through interaction with the Hippo signal transduction pathway. Conditional deletion of Pard3 in the developing rodent cortex resulted in striking subcortical band heterotopia, reminiscent of a severe form of human cortical malformation.
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spelling pubmed-60495182018-12-01 Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling Abdi, Khadar Kuo, Chay T. Genes Dev Outlook During mammalian brain development, radial glial progenitors balance between proliferation and differentiation to generate the laminated cortical layers in a temporally precise fashion. Defects in the individual steps going into this complex organogenesis can result in cortical malformations and human nervous system disorders. In this issue of Genes & Development, Liu and colleagues (pp. 763–780) present experimental evidence that an evolutionarily conserved cellular polarity gene, Pard3 (partitioning-defective 3), controls the balance of radial glial proliferation and differentiation through interaction with the Hippo signal transduction pathway. Conditional deletion of Pard3 in the developing rodent cortex resulted in striking subcortical band heterotopia, reminiscent of a severe form of human cortical malformation. Cold Spring Harbor Laboratory Press 2018-06-01 /pmc/articles/PMC6049518/ /pubmed/29921662 http://dx.doi.org/10.1101/gad.316711.118 Text en © 2018 Abdi and Kuo; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Abdi, Khadar
Kuo, Chay T.
Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title_full Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title_fullStr Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title_full_unstemmed Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title_short Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling
title_sort laminating the mammalian cortex during development: cell polarity protein function and hippo signaling
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049518/
https://www.ncbi.nlm.nih.gov/pubmed/29921662
http://dx.doi.org/10.1101/gad.316711.118
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