High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

A novel Al(18)F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake follow...

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Autores principales: Beard, Rhiannon, Singh, Nisha, Grundschober, Christophe, Gee, Antony D., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049614/
https://www.ncbi.nlm.nih.gov/pubmed/29974895
http://dx.doi.org/10.1039/c8cc01400k
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author Beard, Rhiannon
Singh, Nisha
Grundschober, Christophe
Gee, Antony D.
Tate, Edward W.
author_facet Beard, Rhiannon
Singh, Nisha
Grundschober, Christophe
Gee, Antony D.
Tate, Edward W.
author_sort Beard, Rhiannon
collection PubMed
description A novel Al(18)F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
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spelling pubmed-60496142018-08-03 High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo Beard, Rhiannon Singh, Nisha Grundschober, Christophe Gee, Antony D. Tate, Edward W. Chem Commun (Camb) Chemistry A novel Al(18)F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics. Royal Society of Chemistry 2018-07-25 2018-07-05 /pmc/articles/PMC6049614/ /pubmed/29974895 http://dx.doi.org/10.1039/c8cc01400k Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Beard, Rhiannon
Singh, Nisha
Grundschober, Christophe
Gee, Antony D.
Tate, Edward W.
High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title_full High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title_fullStr High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title_full_unstemmed High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title_short High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
title_sort high-yielding (18)f radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049614/
https://www.ncbi.nlm.nih.gov/pubmed/29974895
http://dx.doi.org/10.1039/c8cc01400k
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