Rapid chromatin repression by Aire provides precise control of immune tolerance

Aire mediates the expression of tissue-specific antigens in thymic epithelial cells to remove dangerous self-reactive T lymphocytes. However, the mechanism that allows expression of tissue-specific genes at levels that prevent harm is unknown. Here we show that Brg1 generates accessibility at tissue...

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Detalles Bibliográficos
Autores principales: Koh, Andrew S., Miller, Erik L., Buenrostro, Jason D., Moskowitz, David M., Wang, Jing, Greenleaf, William J., Chang, Howard Y., Crabtree, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049828/
https://www.ncbi.nlm.nih.gov/pubmed/29335648
http://dx.doi.org/10.1038/s41590-017-0032-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049828/
https://www.ncbi.nlm.nih.gov/pubmed/29335648
http://dx.doi.org/10.1038/s41590-017-0032-8

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