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Rapid chromatin repression by Aire provides precise control of immune tolerance
Aire mediates the expression of tissue-specific antigens in thymic epithelial cells to remove dangerous self-reactive T lymphocytes. However, the mechanism that allows expression of tissue-specific genes at levels that prevent harm is unknown. Here we show that Brg1 generates accessibility at tissue...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049828/ https://www.ncbi.nlm.nih.gov/pubmed/29335648 http://dx.doi.org/10.1038/s41590-017-0032-8 |