Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor

In many cancers, combination therapy regimens are successfully improving response and survival rates, but the challenges of toxicity remain. GRP78, the master regulator of the unfolded protein response, is emerging as a target that is upregulated in tumors, specifically following treatment, and one...

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Detalles Bibliográficos
Autores principales: Bakewell, Suzanne J., Rangel, Daisy F., Ha, Dat P., Sethuraman, Jyothi, Crouse, Richard, Hadley, Emma, Costich, Tara L., Zhou, Xingliang, Nichols, Peter, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049868/
https://www.ncbi.nlm.nih.gov/pubmed/30038714
http://dx.doi.org/10.18632/oncotarget.25679

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