Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition

Breast cancer is a complex disease in which each patient could present several genetic alterations that are therapeutically relevant in cancers. Here we explored the therapeutic benefit of combining PARP and mTOR inhibitors in a context of DNA repair deficiency and PI3K pathway activation. The combi...

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Detalles Bibliográficos
Autores principales: El Botty, Rania, Coussy, Florence, Hatem, Rana, Assayag, Franck, Chateau-Joubert, Sophie, Servely, Jean-Luc, Leboucher, Sophie, Fouillade, Charles, Vacher, Sophie, Ouine, Bérengère, Cartier, Aurélie, de Koning, Leanne, Cottu, Paul, Bièche, Ivan, Marangoni, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049870/
https://www.ncbi.nlm.nih.gov/pubmed/30038706
http://dx.doi.org/10.18632/oncotarget.25640

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