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PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER

BACKGROUND: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. AIM: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence,...

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Autores principales: ALVES, Letícia Biscaino, TSUKAZAN, Maria Teresa, SERAFIM, Ana Elisa, MENDOZA, Rolando, PADOIN, Alexandre Vontobel, BAÚ, Plínio Carlos, MOREIRA, Luis Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049989/
https://www.ncbi.nlm.nih.gov/pubmed/29947692
http://dx.doi.org/10.1590/0102-672020180001e1358
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author ALVES, Letícia Biscaino
TSUKAZAN, Maria Teresa
SERAFIM, Ana Elisa
MENDOZA, Rolando
PADOIN, Alexandre Vontobel
BAÚ, Plínio Carlos
MOREIRA, Luis Fernando
author_facet ALVES, Letícia Biscaino
TSUKAZAN, Maria Teresa
SERAFIM, Ana Elisa
MENDOZA, Rolando
PADOIN, Alexandre Vontobel
BAÚ, Plínio Carlos
MOREIRA, Luis Fernando
author_sort ALVES, Letícia Biscaino
collection PubMed
description BACKGROUND: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. AIM: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors. METHODS: In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive. RESULTS: There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001). CONCLUSION: Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression.
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spelling pubmed-60499892018-07-18 PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER ALVES, Letícia Biscaino TSUKAZAN, Maria Teresa SERAFIM, Ana Elisa MENDOZA, Rolando PADOIN, Alexandre Vontobel BAÚ, Plínio Carlos MOREIRA, Luis Fernando Arq Bras Cir Dig Original Article BACKGROUND: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. AIM: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors. METHODS: In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive. RESULTS: There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001). CONCLUSION: Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression. Colégio Brasileiro de Cirurgia Digestiva 2018-06-21 /pmc/articles/PMC6049989/ /pubmed/29947692 http://dx.doi.org/10.1590/0102-672020180001e1358 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
ALVES, Letícia Biscaino
TSUKAZAN, Maria Teresa
SERAFIM, Ana Elisa
MENDOZA, Rolando
PADOIN, Alexandre Vontobel
BAÚ, Plínio Carlos
MOREIRA, Luis Fernando
PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title_full PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title_fullStr PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title_full_unstemmed PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title_short PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
title_sort prognostic value of carcinoembryonic antigen levels in transoperative peritoneal lavage in patients with gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049989/
https://www.ncbi.nlm.nih.gov/pubmed/29947692
http://dx.doi.org/10.1590/0102-672020180001e1358
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