Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice

Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), is classified into two subgroups, Stx1 and Stx2. Clinical data clearly indicate that Stx2 is associated with more severe toxicity than Stx1, but the molecular mechanism underlying this difference is not fully u...

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Detalles Bibliográficos
Autores principales: Watanabe-Takahashi, Miho, Yamasaki, Shinji, Murata, Masayuki, Kano, Fumi, Motoyama, Jun, Yamate, Jyoji, Omi, Jumpei, Sato, Waka, Ukai, Hirofumi, Shimasaki, Kentaro, Ikegawa, Masaya, Tamura-Nakano, Miwa, Yanoshita, Ryohei, Nishino, Yuri, Miyazawa, Atsuo, Natori, Yasuhiro, Toyama-Sorimachi, Noriko, Nishikawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050230/
https://www.ncbi.nlm.nih.gov/pubmed/30018364
http://dx.doi.org/10.1038/s41598-018-29128-9

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