Cargando…
Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
Over 50 million women are exposed to the risk of malaria during pregnancy every year. Malaria during pregnancy is a leading global cause of maternal morbidity and adverse pregnancy outcomes. Adhesion of Plasmodium falciparum-infected erythrocytes to placental chondroitin-4-sulfate (CSA) has been lin...
Autores principales: | Chêne, Arnaud, Gangnard, Stéphane, Dechavanne, Célia, Dechavanne, Sebastien, Srivastava, Anand, Tétard, Marilou, Hundt, Sophia, Leroy, Odile, Havelange, Nicolas, Viebig, Nicola K., Gamain, Benoît |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050242/ https://www.ncbi.nlm.nih.gov/pubmed/30038803 http://dx.doi.org/10.1038/s41541-018-0064-6 |
Ejemplares similares
-
Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
por: Gangnard, Stéphane, et al.
Publicado: (2015) -
VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design
por: Gangnard, Stéphane, et al.
Publicado: (2019) -
Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA
por: Dorin-Semblat, Dominique, et al.
Publicado: (2019) -
Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain
por: Nunes-Silva, Sofia, et al.
Publicado: (2014) -
Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region
por: Srivastava, Anand, et al.
Publicado: (2011)