Ciliary parathyroid hormone signaling activates transforming growth factor-β to maintain intervertebral disc homeostasis during aging

Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parat...

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Detalles Bibliográficos
Autores principales: Zheng, Liwei, Cao, Yong, Ni, Shuangfei, Qi, Huabin, Ling, Zemin, Xu, Xin, Zou, Xuenong, Wu, Tianding, Deng, Ruoxian, Hu, Bo, Gao, Bo, Chen, Hao, Li, Yusheng, Zhu, Jianxi, Tintani, Francis, Demehri, Shadpour, Jain, Amit, Kebaish, Khaled M., Liao, Shenghui, Séguin, Cheryle A., Crane, Janet L., Wan, Mei, Lu, Hongbin, Sponseller, Paul D., Riley, Lee H., Zhou, Xuedong, Hu, Jianzhong, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050246/
https://www.ncbi.nlm.nih.gov/pubmed/30038820
http://dx.doi.org/10.1038/s41413-018-0022-y

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