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A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen

Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to crystallize. Here, we developed a generalizable approa...

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Detalles Bibliográficos
Autores principales:	Amon, Ron, Grant, Oliver C., Leviatan Ben-Arye, Shani, Makeneni, Spandana, Nivedha, Anita K., Marshanski, Tal, Norn, Christoffer, Yu, Hai, Glushka, John N., Fleishman, Sarel J., Chen, Xi, Woods, Robert J., Padler-Karavani, Vered
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050261/ https://www.ncbi.nlm.nih.gov/pubmed/30018351 http://dx.doi.org/10.1038/s41598-018-29209-9

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