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Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study

With the extension of the egg-laying cycle, the rapid decline in egg quality at late laying period has aroused great concern in the poultry industry. Herein, we performed a genome-wide association study (GWAS) to identify genomic variations associated with egg quality, employing chicken 600 K high-d...

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Autores principales: Liu, Zhuang, Sun, Congjiao, Yan, Yiyuan, Li, Guangqi, Shi, Fengying, Wu, Guiqin, Liu, Aiqiao, Yang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050282/
https://www.ncbi.nlm.nih.gov/pubmed/30018363
http://dx.doi.org/10.1038/s41598-018-29162-7
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author Liu, Zhuang
Sun, Congjiao
Yan, Yiyuan
Li, Guangqi
Shi, Fengying
Wu, Guiqin
Liu, Aiqiao
Yang, Ning
author_facet Liu, Zhuang
Sun, Congjiao
Yan, Yiyuan
Li, Guangqi
Shi, Fengying
Wu, Guiqin
Liu, Aiqiao
Yang, Ning
author_sort Liu, Zhuang
collection PubMed
description With the extension of the egg-laying cycle, the rapid decline in egg quality at late laying period has aroused great concern in the poultry industry. Herein, we performed a genome-wide association study (GWAS) to identify genomic variations associated with egg quality, employing chicken 600 K high-density SNP arrays in a population of 1078 hens at 72 and 80 weeks of age. The results indicated that a genomic region spanning from 8.95 to 9.31 Mb (~0.36 Mb) on GGA13 was significantly associated with the albumen height (AH) and the haugh unit (HU), and the two most significant SNPs accounted for 3.12 ~ 5.75% of the phenotypic variance. Two promising genes, MSX2 and DRD1, were mapped to the narrow significant region, which was involved in embryonic and ovary development and found to be related to egg production, respectively. Moreover, three interesting genes, RHOA, SDF4 and TNFRSF4, identified from three significant loci, were considered to be candidate genes for egg shell colour. Findings in our study could provide worthy theoretical basis and technological support to improve late-stage egg quality for breeders.
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spelling pubmed-60502822018-07-19 Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study Liu, Zhuang Sun, Congjiao Yan, Yiyuan Li, Guangqi Shi, Fengying Wu, Guiqin Liu, Aiqiao Yang, Ning Sci Rep Article With the extension of the egg-laying cycle, the rapid decline in egg quality at late laying period has aroused great concern in the poultry industry. Herein, we performed a genome-wide association study (GWAS) to identify genomic variations associated with egg quality, employing chicken 600 K high-density SNP arrays in a population of 1078 hens at 72 and 80 weeks of age. The results indicated that a genomic region spanning from 8.95 to 9.31 Mb (~0.36 Mb) on GGA13 was significantly associated with the albumen height (AH) and the haugh unit (HU), and the two most significant SNPs accounted for 3.12 ~ 5.75% of the phenotypic variance. Two promising genes, MSX2 and DRD1, were mapped to the narrow significant region, which was involved in embryonic and ovary development and found to be related to egg production, respectively. Moreover, three interesting genes, RHOA, SDF4 and TNFRSF4, identified from three significant loci, were considered to be candidate genes for egg shell colour. Findings in our study could provide worthy theoretical basis and technological support to improve late-stage egg quality for breeders. Nature Publishing Group UK 2018-07-17 /pmc/articles/PMC6050282/ /pubmed/30018363 http://dx.doi.org/10.1038/s41598-018-29162-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Zhuang
Sun, Congjiao
Yan, Yiyuan
Li, Guangqi
Shi, Fengying
Wu, Guiqin
Liu, Aiqiao
Yang, Ning
Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title_full Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title_fullStr Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title_full_unstemmed Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title_short Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
title_sort genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050282/
https://www.ncbi.nlm.nih.gov/pubmed/30018363
http://dx.doi.org/10.1038/s41598-018-29162-7
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