Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

Interferon (IFN)-stimulated genes (ISGs) play crucial roles in the antiviral immune response; however, IFNs also induce negative regulators that attenuate the antiviral response. Here, we show that both viral and bacterial invasion downregulate Nuclear Dbf2-related kinase 1 (NDR1) expression via the...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zhiyong, Qin, Qiang, Wu, Cheng, Li, Hui, Shou, Jia’nan, Yang, Yuting, Gu, Meidi, Ma, Chunmei, Lin, Wenlong, Zou, Yan, Zhang, Yuanyuan, Ma, Feng, Sun, Jihong, Wang, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050289/
https://www.ncbi.nlm.nih.gov/pubmed/30018336
http://dx.doi.org/10.1038/s41467-018-05176-7

Ejemplares similares

Ejemplares similares