Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch

Bistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However...

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Detalles Bibliográficos
Autores principales: Fang, Xiaona, Liu, Qiong, Bohrer, Christopher, Hensel, Zach, Han, Wei, Wang, Jin, Xiao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050291/
https://www.ncbi.nlm.nih.gov/pubmed/30018349
http://dx.doi.org/10.1038/s41467-018-05071-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050291/
https://www.ncbi.nlm.nih.gov/pubmed/30018349
http://dx.doi.org/10.1038/s41467-018-05071-1

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