Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis

Lymphatic metastasis is known to contribute to worse prognosis of biliary tract cancer (BTC). Recently, sphingosine-1-phosphate (S1P), a bioactive lipid mediator generated by sphingosine kinase 1 (SPHK1), has been shown to play an important role in lymphangiogenesis and lymph node metastasis in seve...

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Detalles Bibliográficos
Autores principales: Hirose, Yuki, Nagahashi, Masayuki, Katsuta, Eriko, Yuza, Kizuki, Miura, Kohei, Sakata, Jun, Kobayashi, Takashi, Ichikawa, Hiroshi, Shimada, Yoshifumi, Kameyama, Hitoshi, McDonald, Kerry-Ann, Takabe, Kazuaki, Wakai, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050292/
https://www.ncbi.nlm.nih.gov/pubmed/30018456
http://dx.doi.org/10.1038/s41598-018-29144-9

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