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Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Cas12a (also called Cpf1) is a representative type V-A CRISPR effector RNA-guided DNA endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing. Previous studies have revealed that Cas12a has unique features distinct from Cas9, but the detailed mechanisms of target search...

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Detalles Bibliográficos
Autores principales:	Jeon, Yongmoon, Choi, You Hee, Jang, Yunsu, Yu, Jihyeon, Goo, Jiyoung, Lee, Gyejun, Jeong, You Kyeong, Lee, Seung Hwan, Kim, In-San, Kim, Jin-Soo, Jeong, Cherlhyun, Lee, Sanghwa, Bae, Sangsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050341/ https://www.ncbi.nlm.nih.gov/pubmed/30018371 http://dx.doi.org/10.1038/s41467-018-05245-x

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