Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2). CGD patients are prone to infection, but also have an increased susceptibility to autoimmune diseases. The aim of this...

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Detalles Bibliográficos
Autores principales: Cachat, Julien, Deffert, Christine, Alessandrini, Marco, Roux-Lombard, Pascale, Le Gouellec, Audrey, Stasia, Marie-José, Hugues, Stéphanie, Krause, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050363/
https://www.ncbi.nlm.nih.gov/pubmed/30050527
http://dx.doi.org/10.3389/fimmu.2018.01555

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