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Probenecid Pre-treatment Downregulates the Kidney Cl(-)/HCO(3)(-) Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl(-)/HCO(3)(-) exchanger, pendrin. In the kidney, pendrin blunts the loss of salt wasting secondary to the inhibition of the th...

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Detalles Bibliográficos
Autores principales:	Barone, Sharon, Xu, Jie, Zahedi, Kamyar, Brooks, Marybeth, Soleimani, Manoocher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050369/ https://www.ncbi.nlm.nih.gov/pubmed/30050451 http://dx.doi.org/10.3389/fphys.2018.00849

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