Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

The indoleamine 2,3-dioxygenase (IDO) enzyme can act as an immunoregulator by inhibiting T cell function via the degradation of the essential amino acid tryptophan (trp) into kynurenine (kyn) and its derivates. The kyn/trp ratio in serum is a prognostic factor for cervical cancer patients; however,...

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Detalles Bibliográficos
Autores principales: Heeren, A. Marijne, van Dijk, Ilse, Berry, Daniella R. A. I., Khelil, Maryam, Ferns, Debbie, Kole, Jeroen, Musters, René J. P., Thijssen, Victor L., Mom, Constantijne H., Kenter, Gemma G., Bleeker, Maaike C. G., de Gruijl, Tanja D., Jordanova, Ekaterina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050387/
https://www.ncbi.nlm.nih.gov/pubmed/30050535
http://dx.doi.org/10.3389/fimmu.2018.01598

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