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Endothelial microvesicles in hypoxic hypoxia diseases

Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction‐induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specifi...

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Autores principales: Deng, Fan, Wang, Shuang, Xu, Riping, Yu, Wenqian, Wang, Xianyu, Zhang, Liangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050493/
https://www.ncbi.nlm.nih.gov/pubmed/29808945
http://dx.doi.org/10.1111/jcmm.13671
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author Deng, Fan
Wang, Shuang
Xu, Riping
Yu, Wenqian
Wang, Xianyu
Zhang, Liangqing
author_facet Deng, Fan
Wang, Shuang
Xu, Riping
Yu, Wenqian
Wang, Xianyu
Zhang, Liangqing
author_sort Deng, Fan
collection PubMed
description Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction‐induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specific characteristics include reduced arterial oxygen partial pressure and oxygen content. Hypoxic hypoxia diseases (HHDs) have attracted increased attention due to their high morbidity and mortality and mounting evidence showing that hypoxia‐induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of HHDs‐related vascular endothelial injury. Interestingly, endothelial microvesicles (EMVs), which can be induced by hypoxia, hypoxia‐induced oxidative stress, coagulation and inflammation in HHDs, have emerged as key mediators of intercellular communication and cellular functions. EMVs shed from activated or apoptotic endothelial cells (ECs) reflect the degree of ECs damage, and elevated EMVs levels are present in several HHDs, including obstructive sleep apnoea syndrome and chronic obstructive pulmonary disease. Furthermore, EMVs have procoagulant, proinflammatory and angiogenic functions that affect the pathological processes of HHDs. This review summarizes the emerging roles of EMVs in the diagnosis, staging, treatment and clinical prognosis of HHDs.
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spelling pubmed-60504932018-08-01 Endothelial microvesicles in hypoxic hypoxia diseases Deng, Fan Wang, Shuang Xu, Riping Yu, Wenqian Wang, Xianyu Zhang, Liangqing J Cell Mol Med Reviews Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction‐induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specific characteristics include reduced arterial oxygen partial pressure and oxygen content. Hypoxic hypoxia diseases (HHDs) have attracted increased attention due to their high morbidity and mortality and mounting evidence showing that hypoxia‐induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of HHDs‐related vascular endothelial injury. Interestingly, endothelial microvesicles (EMVs), which can be induced by hypoxia, hypoxia‐induced oxidative stress, coagulation and inflammation in HHDs, have emerged as key mediators of intercellular communication and cellular functions. EMVs shed from activated or apoptotic endothelial cells (ECs) reflect the degree of ECs damage, and elevated EMVs levels are present in several HHDs, including obstructive sleep apnoea syndrome and chronic obstructive pulmonary disease. Furthermore, EMVs have procoagulant, proinflammatory and angiogenic functions that affect the pathological processes of HHDs. This review summarizes the emerging roles of EMVs in the diagnosis, staging, treatment and clinical prognosis of HHDs. John Wiley and Sons Inc. 2018-05-29 2018-08 /pmc/articles/PMC6050493/ /pubmed/29808945 http://dx.doi.org/10.1111/jcmm.13671 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Deng, Fan
Wang, Shuang
Xu, Riping
Yu, Wenqian
Wang, Xianyu
Zhang, Liangqing
Endothelial microvesicles in hypoxic hypoxia diseases
title Endothelial microvesicles in hypoxic hypoxia diseases
title_full Endothelial microvesicles in hypoxic hypoxia diseases
title_fullStr Endothelial microvesicles in hypoxic hypoxia diseases
title_full_unstemmed Endothelial microvesicles in hypoxic hypoxia diseases
title_short Endothelial microvesicles in hypoxic hypoxia diseases
title_sort endothelial microvesicles in hypoxic hypoxia diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050493/
https://www.ncbi.nlm.nih.gov/pubmed/29808945
http://dx.doi.org/10.1111/jcmm.13671
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