Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase

Cellular uptake of circulating cholesterol occurs via the low density lipoprotein receptor (LDLR). The E3 ubiquitin ligase IDOL is a mediator of LDLR degradation, with IDOL homodimerization thought to be required for its activity. To probe the possibility of modulating LDLR levels with an inhibitor...

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Detalles Bibliográficos
Autores principales: Leitch, Eilidh K., Elumalai, Nagarajan, Fridén-Saxin, Maria, Dahl, Göran, Wan, Paul, Clarkson, Paul, Valeur, Eric, Pairaudeau, Garry, Boyd, Helen, Tavassoli, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050537/
https://www.ncbi.nlm.nih.gov/pubmed/30079210
http://dx.doi.org/10.1039/c8sc01186a

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