Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarkar, Rahul, Mitra, Sankash, Mukherjee, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050583/
https://www.ncbi.nlm.nih.gov/pubmed/30079186
http://dx.doi.org/10.1039/c8sc02041h
_version_ 1783340368049209344
author Sarkar, Rahul
Mitra, Sankash
Mukherjee, Santanu
author_facet Sarkar, Rahul
Mitra, Sankash
Mukherjee, Santanu
author_sort Sarkar, Rahul
collection PubMed
description The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er).
format Online
Article
Text
id pubmed-6050583
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-60505832018-08-03 Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins Sarkar, Rahul Mitra, Sankash Mukherjee, Santanu Chem Sci Chemistry The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er). Royal Society of Chemistry 2018-06-04 /pmc/articles/PMC6050583/ /pubmed/30079186 http://dx.doi.org/10.1039/c8sc02041h Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Sarkar, Rahul
Mitra, Sankash
Mukherjee, Santanu
Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title_full Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title_fullStr Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title_full_unstemmed Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title_short Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
title_sort iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050583/
https://www.ncbi.nlm.nih.gov/pubmed/30079186
http://dx.doi.org/10.1039/c8sc02041h
work_keys_str_mv AT sarkarrahul iridiumcatalyzedenantioselectivedirectvinylogousallylicalkylationofcoumarins
AT mitrasankash iridiumcatalyzedenantioselectivedirectvinylogousallylicalkylationofcoumarins
AT mukherjeesantanu iridiumcatalyzedenantioselectivedirectvinylogousallylicalkylationofcoumarins

Ejemplares similares