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Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
Reversibly controlled generation of singlet oxygen from photosensitizing nanosystems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We report a strategy for integrating photochromic spiropyrans into biocompatible catio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050604/ https://www.ncbi.nlm.nih.gov/pubmed/30079193 http://dx.doi.org/10.1039/c8sc01148f |
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author | Ji, Jinkai Li, Xiao Wu, Tiantian Feng, Fude |
author_facet | Ji, Jinkai Li, Xiao Wu, Tiantian Feng, Fude |
author_sort | Ji, Jinkai |
collection | PubMed |
description | Reversibly controlled generation of singlet oxygen from photosensitizing nanosystems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We report a strategy for integrating photochromic spiropyrans into biocompatible cationic polymers, which involved assembling nucleic acids into functional nanoparticles without introducing additional photosensitizers and imaging agents. We found that spiropyran-containing nanoparticles have photoswitching properties for both fluorescence (with a quantum yield of up to 0.27) and singlet oxygen generation (with a quantum yield of up to 0.22) in aqueous solutions and cells, and demonstrated that spiropyrans in nanoassemblies featuring aggregation-induced enhanced photosensitization and emission could be potentially applied in photodynamic therapy studies on tumor cells. |
format | Online Article Text |
id | pubmed-6050604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-60506042018-08-03 Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells Ji, Jinkai Li, Xiao Wu, Tiantian Feng, Fude Chem Sci Chemistry Reversibly controlled generation of singlet oxygen from photosensitizing nanosystems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We report a strategy for integrating photochromic spiropyrans into biocompatible cationic polymers, which involved assembling nucleic acids into functional nanoparticles without introducing additional photosensitizers and imaging agents. We found that spiropyran-containing nanoparticles have photoswitching properties for both fluorescence (with a quantum yield of up to 0.27) and singlet oxygen generation (with a quantum yield of up to 0.22) in aqueous solutions and cells, and demonstrated that spiropyrans in nanoassemblies featuring aggregation-induced enhanced photosensitization and emission could be potentially applied in photodynamic therapy studies on tumor cells. Royal Society of Chemistry 2018-06-11 /pmc/articles/PMC6050604/ /pubmed/30079193 http://dx.doi.org/10.1039/c8sc01148f Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0) |
spellingShingle | Chemistry Ji, Jinkai Li, Xiao Wu, Tiantian Feng, Fude Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells |
title | Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
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title_full | Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
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title_fullStr | Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
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title_full_unstemmed | Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
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title_short | Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
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title_sort | spiropyran in nanoassemblies as a photosensitizer for photoswitchable ros generation in living cells |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050604/ https://www.ncbi.nlm.nih.gov/pubmed/30079193 http://dx.doi.org/10.1039/c8sc01148f |
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