Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives

Functionalization of heterocyclic scaffolds with mono- or difluoroalkyl groups provides unique opportunities to modulate drug pK(a), influence potency and membrane permeability, and attenuate metabolism. While advances in the addition of fluoroalkyl radicals to heterocycles have been made, direct C(...

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Detalles Bibliográficos
Autores principales: Meanwell, Michael, Adluri, Bharani Shashank, Yuan, Zheliang, Newton, Josiah, Prevost, Philippe, Nodwell, Matthew B., Friesen, Chadron M., Schaffer, Paul, Martin, Rainer E., Britton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050628/
https://www.ncbi.nlm.nih.gov/pubmed/30061993
http://dx.doi.org/10.1039/c8sc01221k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050628/
https://www.ncbi.nlm.nih.gov/pubmed/30061993
http://dx.doi.org/10.1039/c8sc01221k

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