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A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

BACKGROUND: The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimethoprim-sulfamethoxazole (TMP-SMX), suffer from significant treatment failures...

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Detalles Bibliográficos
Autores principales:	Liu, Guan-Sheng, Ballweg, Richard, Ashbaugh, Alan, Zhang, Yin, Facciolo, Joseph, Cushion, Melanie T., Zhang, Tongli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050661/ https://www.ncbi.nlm.nih.gov/pubmed/30016951 http://dx.doi.org/10.1186/s12918-018-0603-9

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