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Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

BACKGROUND: Human anelloviruses (TTV, TTMDV and TTMV) are at high prevalence all across the globe, having also a controversial disease-inducing potential. This study aimed to estimate the prevalence of anelloviral DNA in the Romanian human population and to investigate the association of infections...

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Autores principales: Spandole-Dinu, Sonia, Cimponeriu, Dănuț Gheorghe, Crăciun, Anne-Marie, Radu, Irina, Nica, Silvia, Toma, Mihai, Alexiu, Oana Andrada, Iorga, Corneliu Sorin, Berca, Lavinia-Mariana, Nica, Remus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050727/
https://www.ncbi.nlm.nih.gov/pubmed/30016934
http://dx.doi.org/10.1186/s12879-018-3248-9
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author Spandole-Dinu, Sonia
Cimponeriu, Dănuț Gheorghe
Crăciun, Anne-Marie
Radu, Irina
Nica, Silvia
Toma, Mihai
Alexiu, Oana Andrada
Iorga, Corneliu Sorin
Berca, Lavinia-Mariana
Nica, Remus
author_facet Spandole-Dinu, Sonia
Cimponeriu, Dănuț Gheorghe
Crăciun, Anne-Marie
Radu, Irina
Nica, Silvia
Toma, Mihai
Alexiu, Oana Andrada
Iorga, Corneliu Sorin
Berca, Lavinia-Mariana
Nica, Remus
author_sort Spandole-Dinu, Sonia
collection PubMed
description BACKGROUND: Human anelloviruses (TTV, TTMDV and TTMV) are at high prevalence all across the globe, having also a controversial disease-inducing potential. This study aimed to estimate the prevalence of anelloviral DNA in the Romanian human population and to investigate the association of infections with common pathologies in Romanian population. METHODS: After informed consent, blood samples were collected from 2000 subjects represented by: clinically healthy individuals (n = 701) and a group of patients with pathologies linked to low grade inflammation or alteration of carbohydrate metabolism (n = 1299). All samples were analysed for the presence of TTV, TTMDV and TTMV DNA by hemi-nested PCR. RESULTS: The prevalence of TTV, TTMDV and TTMV in the studied population was 68.2, 54.4%, respectively 40.1%, lower than the recent reports from other geographic regions. The three viral species were significantly more frequent in the group of patients compared to the healthy subjects and were associated with type 2 diabetes mellitus. The presence of anelloviral DNA was also associated with medical procedures (e.g. haemodialysis/transfusions, surgical procedures) and previous hepatitis A virus infection. Lifestyle choices related to alcohol consumption, smoking, physical activity and living environment were not associated with differences in distribution of the three viruses. CONCLUSION: Further evidence is needed to establish a correlation between infection with human anelloviruses and a pathology or group of pathologies.
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spelling pubmed-60507272018-07-19 Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies Spandole-Dinu, Sonia Cimponeriu, Dănuț Gheorghe Crăciun, Anne-Marie Radu, Irina Nica, Silvia Toma, Mihai Alexiu, Oana Andrada Iorga, Corneliu Sorin Berca, Lavinia-Mariana Nica, Remus BMC Infect Dis Research Article BACKGROUND: Human anelloviruses (TTV, TTMDV and TTMV) are at high prevalence all across the globe, having also a controversial disease-inducing potential. This study aimed to estimate the prevalence of anelloviral DNA in the Romanian human population and to investigate the association of infections with common pathologies in Romanian population. METHODS: After informed consent, blood samples were collected from 2000 subjects represented by: clinically healthy individuals (n = 701) and a group of patients with pathologies linked to low grade inflammation or alteration of carbohydrate metabolism (n = 1299). All samples were analysed for the presence of TTV, TTMDV and TTMV DNA by hemi-nested PCR. RESULTS: The prevalence of TTV, TTMDV and TTMV in the studied population was 68.2, 54.4%, respectively 40.1%, lower than the recent reports from other geographic regions. The three viral species were significantly more frequent in the group of patients compared to the healthy subjects and were associated with type 2 diabetes mellitus. The presence of anelloviral DNA was also associated with medical procedures (e.g. haemodialysis/transfusions, surgical procedures) and previous hepatitis A virus infection. Lifestyle choices related to alcohol consumption, smoking, physical activity and living environment were not associated with differences in distribution of the three viruses. CONCLUSION: Further evidence is needed to establish a correlation between infection with human anelloviruses and a pathology or group of pathologies. BioMed Central 2018-07-17 /pmc/articles/PMC6050727/ /pubmed/30016934 http://dx.doi.org/10.1186/s12879-018-3248-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Spandole-Dinu, Sonia
Cimponeriu, Dănuț Gheorghe
Crăciun, Anne-Marie
Radu, Irina
Nica, Silvia
Toma, Mihai
Alexiu, Oana Andrada
Iorga, Corneliu Sorin
Berca, Lavinia-Mariana
Nica, Remus
Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title_full Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title_fullStr Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title_full_unstemmed Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title_short Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies
title_sort prevalence of human anelloviruses in romanian healthy subjects and patients with common pathologies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050727/
https://www.ncbi.nlm.nih.gov/pubmed/30016934
http://dx.doi.org/10.1186/s12879-018-3248-9
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