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Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases
BACKGROUND AND OBJECTIVES: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. DESIGN AND SET...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050787/ https://www.ncbi.nlm.nih.gov/pubmed/30069084 http://dx.doi.org/10.4103/jnrp.jnrp_576_17 |
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author | Gupta, Meenu Bansal, Saurabh Pruthi, Deep Shankar Saini, Manju Shirazi, Nadia Ahmad, Mushtaq |
author_facet | Gupta, Meenu Bansal, Saurabh Pruthi, Deep Shankar Saini, Manju Shirazi, Nadia Ahmad, Mushtaq |
author_sort | Gupta, Meenu |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. DESIGN AND SETTING: Retrospective analysis of 24 elderly patients of ≥60 years with newly diagnosed HGGs, who were treated at our department between January 2009 and December 2012, was done. PATIENTS AND METHODS: Age, gender, Karnofsky performance scale (KPS) score, extent of surgery, and use of temozolomide were evaluated using univariate and multivariate analyses. Survival was determined using the Kaplan–Meier method, and differences were compared using the log-rank test. Cox regression analysis was conducted to identify the independent prognostic factors. RESULTS: The median overall survival of the patient cohort was 10 months. The 1- and 2-year survival rates were 45.8% and 16.6%, respectively. The analysis revealed that KPS score and use of concomitant chemotherapy were significant prognostic factors. CONCLUSION: The results of our analyses demonstrate that KPS score and use of concomitant chemotherapy yield encouraging outcomes in elderly patients with HGGs, validating the results published in research papers. |
format | Online Article Text |
id | pubmed-6050787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60507872018-08-01 Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases Gupta, Meenu Bansal, Saurabh Pruthi, Deep Shankar Saini, Manju Shirazi, Nadia Ahmad, Mushtaq J Neurosci Rural Pract Original Article BACKGROUND AND OBJECTIVES: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. DESIGN AND SETTING: Retrospective analysis of 24 elderly patients of ≥60 years with newly diagnosed HGGs, who were treated at our department between January 2009 and December 2012, was done. PATIENTS AND METHODS: Age, gender, Karnofsky performance scale (KPS) score, extent of surgery, and use of temozolomide were evaluated using univariate and multivariate analyses. Survival was determined using the Kaplan–Meier method, and differences were compared using the log-rank test. Cox regression analysis was conducted to identify the independent prognostic factors. RESULTS: The median overall survival of the patient cohort was 10 months. The 1- and 2-year survival rates were 45.8% and 16.6%, respectively. The analysis revealed that KPS score and use of concomitant chemotherapy were significant prognostic factors. CONCLUSION: The results of our analyses demonstrate that KPS score and use of concomitant chemotherapy yield encouraging outcomes in elderly patients with HGGs, validating the results published in research papers. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6050787/ /pubmed/30069084 http://dx.doi.org/10.4103/jnrp.jnrp_576_17 Text en Copyright: © 2018 Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Gupta, Meenu Bansal, Saurabh Pruthi, Deep Shankar Saini, Manju Shirazi, Nadia Ahmad, Mushtaq Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title | Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title_full | Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title_fullStr | Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title_full_unstemmed | Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title_short | Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases |
title_sort | prognostic factors in elderly patients with high-grade gliomas: a retrospective analysis of 24 cases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050787/ https://www.ncbi.nlm.nih.gov/pubmed/30069084 http://dx.doi.org/10.4103/jnrp.jnrp_576_17 |
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