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Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies
BACKGROUND: Germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors in the West, whereas in Asia, they constitute between 8% and 15% of pediatric brain tumors. METHODS: We retrospectively studied all patients with intracranial GCT managed at our institute from January 19...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050793/ https://www.ncbi.nlm.nih.gov/pubmed/30069081 http://dx.doi.org/10.4103/jnrp.jnrp_86_18 |
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author | Borde, Tushar Deepak Arimappamagan, Arivazhagan Srinivas, Dwarakanath Narasinga Rao, K. V. L. Devi, B. Indira Somanna, Sampath Santosh, Vani |
author_facet | Borde, Tushar Deepak Arimappamagan, Arivazhagan Srinivas, Dwarakanath Narasinga Rao, K. V. L. Devi, B. Indira Somanna, Sampath Santosh, Vani |
author_sort | Borde, Tushar Deepak |
collection | PubMed |
description | BACKGROUND: Germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors in the West, whereas in Asia, they constitute between 8% and 15% of pediatric brain tumors. METHODS: We retrospectively studied all patients with intracranial GCT managed at our institute from January 1998 to December 2013. The clinical data and radiological data were analyzed. RESULTS: Forty-eight patients with intracranial GCT including 36 males and 16 females formed the cohort. The proportion of GCT in our study was 0.29%. The mean age was 16.5 ± 2.5 years. Germinomas constituted 56.3% and nongerminomatous GCTs constituted 43.7% of all the tumors. The most common location was posterior third ventricle (58.3%) followed by suprasellar (22.9%). Histopathological diagnosis was obtained in almost all patients (96%). Surgical procedures included tumor decompression (71.7%), stereotactic biopsy (13%), and endoscopic third ventriculostomy and biopsy (15%). Patient's age, location of the tumor, and histology did not influence the survival. Women with GCTs had poorer survival when compared to men. CONCLUSIONS: The present study documented a lower hospital-based incidence of GCT in Indian cohort. A multidisciplinary approach including surgical strategy based on location, appropriate radiation planning, and chemotherapy is needed for effective treatment and improved outcomes. |
format | Online Article Text |
id | pubmed-6050793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60507932018-08-01 Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies Borde, Tushar Deepak Arimappamagan, Arivazhagan Srinivas, Dwarakanath Narasinga Rao, K. V. L. Devi, B. Indira Somanna, Sampath Santosh, Vani J Neurosci Rural Pract Original Article BACKGROUND: Germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors in the West, whereas in Asia, they constitute between 8% and 15% of pediatric brain tumors. METHODS: We retrospectively studied all patients with intracranial GCT managed at our institute from January 1998 to December 2013. The clinical data and radiological data were analyzed. RESULTS: Forty-eight patients with intracranial GCT including 36 males and 16 females formed the cohort. The proportion of GCT in our study was 0.29%. The mean age was 16.5 ± 2.5 years. Germinomas constituted 56.3% and nongerminomatous GCTs constituted 43.7% of all the tumors. The most common location was posterior third ventricle (58.3%) followed by suprasellar (22.9%). Histopathological diagnosis was obtained in almost all patients (96%). Surgical procedures included tumor decompression (71.7%), stereotactic biopsy (13%), and endoscopic third ventriculostomy and biopsy (15%). Patient's age, location of the tumor, and histology did not influence the survival. Women with GCTs had poorer survival when compared to men. CONCLUSIONS: The present study documented a lower hospital-based incidence of GCT in Indian cohort. A multidisciplinary approach including surgical strategy based on location, appropriate radiation planning, and chemotherapy is needed for effective treatment and improved outcomes. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6050793/ /pubmed/30069081 http://dx.doi.org/10.4103/jnrp.jnrp_86_18 Text en Copyright: © 2018 Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Borde, Tushar Deepak Arimappamagan, Arivazhagan Srinivas, Dwarakanath Narasinga Rao, K. V. L. Devi, B. Indira Somanna, Sampath Santosh, Vani Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title | Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title_full | Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title_fullStr | Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title_full_unstemmed | Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title_short | Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies |
title_sort | intracranial germ cell tumors: spectrum of disease in an indian cohort and management strategies |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050793/ https://www.ncbi.nlm.nih.gov/pubmed/30069081 http://dx.doi.org/10.4103/jnrp.jnrp_86_18 |
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