DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate

BACKGROUND: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. OBJECTIVE: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4(+) T cells of multiple sclerosis patients. METHODS: We performed Illumina EPIC arrays...

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Detalles Bibliográficos
Autores principales: Maltby, Vicki E, Lea, Rodney A, Ribbons, Karen A, Sanders, Katherine A, Kennedy, Daniel, Min, Myintzu, Scott, Rodney J, Lechner-Scott, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050818/
https://www.ncbi.nlm.nih.gov/pubmed/30038789
http://dx.doi.org/10.1177/2055217318787826
Descripción
Sumario:BACKGROUND: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. OBJECTIVE: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4(+) T cells of multiple sclerosis patients. METHODS: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4(+) T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. RESULTS: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. CONCLUSION: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.

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