DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate

BACKGROUND: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. OBJECTIVE: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4(+) T cells of multiple sclerosis patients. METHODS: We performed Illumina EPIC arrays...

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Autores principales: Maltby, Vicki E, Lea, Rodney A, Ribbons, Karen A, Sanders, Katherine A, Kennedy, Daniel, Min, Myintzu, Scott, Rodney J, Lechner-Scott, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050818/
https://www.ncbi.nlm.nih.gov/pubmed/30038789
http://dx.doi.org/10.1177/2055217318787826
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author Maltby, Vicki E
Lea, Rodney A
Ribbons, Karen A
Sanders, Katherine A
Kennedy, Daniel
Min, Myintzu
Scott, Rodney J
Lechner-Scott, Jeannette
author_facet Maltby, Vicki E
Lea, Rodney A
Ribbons, Karen A
Sanders, Katherine A
Kennedy, Daniel
Min, Myintzu
Scott, Rodney J
Lechner-Scott, Jeannette
author_sort Maltby, Vicki E
collection PubMed
description BACKGROUND: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. OBJECTIVE: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4(+) T cells of multiple sclerosis patients. METHODS: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4(+) T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. RESULTS: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. CONCLUSION: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
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spelling pubmed-60508182018-07-23 DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate Maltby, Vicki E Lea, Rodney A Ribbons, Karen A Sanders, Katherine A Kennedy, Daniel Min, Myintzu Scott, Rodney J Lechner-Scott, Jeannette Mult Scler J Exp Transl Clin Short Report BACKGROUND: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. OBJECTIVE: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4(+) T cells of multiple sclerosis patients. METHODS: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4(+) T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. RESULTS: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. CONCLUSION: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients. SAGE Publications 2018-07-17 /pmc/articles/PMC6050818/ /pubmed/30038789 http://dx.doi.org/10.1177/2055217318787826 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Report
Maltby, Vicki E
Lea, Rodney A
Ribbons, Karen A
Sanders, Katherine A
Kennedy, Daniel
Min, Myintzu
Scott, Rodney J
Lechner-Scott, Jeannette
DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title_full DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title_fullStr DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title_full_unstemmed DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title_short DNA methylation changes in CD4(+) T cells isolated from multiple sclerosis patients on dimethyl fumarate
title_sort dna methylation changes in cd4(+) t cells isolated from multiple sclerosis patients on dimethyl fumarate
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050818/
https://www.ncbi.nlm.nih.gov/pubmed/30038789
http://dx.doi.org/10.1177/2055217318787826
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