Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1

Flutamide is a widely used nonsteroidal antiandrogen for prostate cancer therapy, but its clinical application is restricted by the concurrent liver injury. Increasing evidence suggests that flutamide-induced liver injury is associated with oxidative stress, though the precise mechanism is poorly un...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Guo, Jiabin, Zhang, Qiang, Zhou, Wei, Li, Jin, Yin, Jian, Cui, Lan, Zhang, Tingfen, Zhao, Jun, Carmichael, Paul L., Middleton, Alistair, Peng, Shuangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051009/
https://www.ncbi.nlm.nih.gov/pubmed/30057686
http://dx.doi.org/10.1155/2018/8017073

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