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Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender

Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session. The influence of diabetes mellitus and sex on oxidation of plasma proteins in ESRD has not yet been clarified despite that diabetic n...

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Autores principales: Colombo, Graziano, Reggiani, Francesco, Cucchiari, David, Astori, Emanuela, Garavaglia, Maria L., Portinaro, Nicola M., Saino, Nicola, Finazzi, Silvia, Milzani, Aldo, Badalamenti, Salvatore, Dalle-Donne, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051011/
https://www.ncbi.nlm.nih.gov/pubmed/30057679
http://dx.doi.org/10.1155/2018/4149681
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author Colombo, Graziano
Reggiani, Francesco
Cucchiari, David
Astori, Emanuela
Garavaglia, Maria L.
Portinaro, Nicola M.
Saino, Nicola
Finazzi, Silvia
Milzani, Aldo
Badalamenti, Salvatore
Dalle-Donne, Isabella
author_facet Colombo, Graziano
Reggiani, Francesco
Cucchiari, David
Astori, Emanuela
Garavaglia, Maria L.
Portinaro, Nicola M.
Saino, Nicola
Finazzi, Silvia
Milzani, Aldo
Badalamenti, Salvatore
Dalle-Donne, Isabella
author_sort Colombo, Graziano
collection PubMed
description Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session. The influence of diabetes mellitus and sex on oxidation of plasma proteins in ESRD has not yet been clarified despite that diabetic nephropathy is the most common cause of ESRD in developed and developing countries and despite the increasingly emerging differences between males and females in epidemiology, pathophysiology, clinical manifestations, and outcomes for several diseases. Therefore, this study aimed to evaluate the possible effect of type 2 diabetes mellitus, gender, and dialysis filter on plasma level of protein carbonyls (PCO) in ESRD patients at the beginning and at the end of a single HD session. Results show that mean post-HD plasma PCO levels are significantly higher than mean pre-HD plasma PCO levels and that the type of dialysis filter and dialysis technique are unrelated to plasma PCO levels. The mean level of plasma PCO after a HD session increases slightly but significantly in nondiabetic ESRD patients compared to diabetic ones, whereas it increases more markedly in women than in men. These novel findings suggest that women with ESRD are more susceptible than men to oxidative/carbonyl stress induced by HD.
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spelling pubmed-60510112018-07-29 Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender Colombo, Graziano Reggiani, Francesco Cucchiari, David Astori, Emanuela Garavaglia, Maria L. Portinaro, Nicola M. Saino, Nicola Finazzi, Silvia Milzani, Aldo Badalamenti, Salvatore Dalle-Donne, Isabella Oxid Med Cell Longev Research Article Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session. The influence of diabetes mellitus and sex on oxidation of plasma proteins in ESRD has not yet been clarified despite that diabetic nephropathy is the most common cause of ESRD in developed and developing countries and despite the increasingly emerging differences between males and females in epidemiology, pathophysiology, clinical manifestations, and outcomes for several diseases. Therefore, this study aimed to evaluate the possible effect of type 2 diabetes mellitus, gender, and dialysis filter on plasma level of protein carbonyls (PCO) in ESRD patients at the beginning and at the end of a single HD session. Results show that mean post-HD plasma PCO levels are significantly higher than mean pre-HD plasma PCO levels and that the type of dialysis filter and dialysis technique are unrelated to plasma PCO levels. The mean level of plasma PCO after a HD session increases slightly but significantly in nondiabetic ESRD patients compared to diabetic ones, whereas it increases more markedly in women than in men. These novel findings suggest that women with ESRD are more susceptible than men to oxidative/carbonyl stress induced by HD. Hindawi 2018-07-02 /pmc/articles/PMC6051011/ /pubmed/30057679 http://dx.doi.org/10.1155/2018/4149681 Text en Copyright © 2018 Graziano Colombo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Colombo, Graziano
Reggiani, Francesco
Cucchiari, David
Astori, Emanuela
Garavaglia, Maria L.
Portinaro, Nicola M.
Saino, Nicola
Finazzi, Silvia
Milzani, Aldo
Badalamenti, Salvatore
Dalle-Donne, Isabella
Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title_full Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title_fullStr Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title_full_unstemmed Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title_short Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
title_sort plasma protein carbonylation in haemodialysed patients: focus on diabetes and gender
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051011/
https://www.ncbi.nlm.nih.gov/pubmed/30057679
http://dx.doi.org/10.1155/2018/4149681
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