Cargando…

Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Biyu, Zhao, Yuerong, Qiang, Guifen, Yang, Xiuying, Xu, Chunyang, Chen, Xi, Liu, Chenge, Wang, Xiaobo, Zhang, Li, Du, Guanhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051041/ https://www.ncbi.nlm.nih.gov/pubmed/30057680 http://dx.doi.org/10.1155/2018/4545321

Ejemplares similares

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2
por: Xu, Chunyang, et al.
Publicado: (2020)

Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy
por: Hou, Biyu, et al.
Publicado: (2020)

Chronopharmacokinetics of Puerarin in Diabetic Rats
por: Zhang, C. T., et al.
Publicado: (2013)

Improvement of hepatic steatosis and fibrosis in diabetes: Which bariatric procedure is more appropriate?
por: Jia, Weiping
Publicado: (2022)

Hepatic Fibrosis and Steatosis in Metabolic Syndrome
por: Gangireddy, Venu Gopala Reddy, et al.
Publicado: (2022)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
por: Li, Xueling, et al.
Publicado: (2020)

Molecular Mechanism of Puerarin Against Diabetes and its Complications
por: Bai, Yi-ling, et al.
Publicado: (2022)

Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation
por: He, Ping, et al.
Publicado: (2019)

Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung
por: Wang, Zijing, et al.
Publicado: (2021)

Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer's disease mice
por: Zhang, Yu, et al.
Publicado: (2018)

Hepatic steatosis and fibrosis: Non-invasive assessment
por: Karanjia, Rustam N, et al.
Publicado: (2016)

Effects of puerarin on the retina and STAT3 expression in diabetic rats
por: Cai, Yonghao, et al.
Publicado: (2017)

Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice
por: Zhu, Qian, et al.
Publicado: (2023)

Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-catenin signalling pathway
por: Huang, Gan-Rong, et al.
Publicado: (2018)

Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition
por: Jin, Ya-Ge, et al.
Publicado: (2017)

Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats
por: Li, Zhen, et al.
Publicado: (2022)

The association of hepatic steatosis and fibrosis with heart failure and mortality
por: Park, Jiyun, et al.
Publicado: (2021)

Hepatic Steatosis and Fibrosis in Chronic Inflammatory Bowel Disease
por: Veltkamp, Claudia, et al.
Publicado: (2022)

Alleviation of Inflammatory Response of Pulmonary Fibrosis in Acute Respiratory Distress Syndrome by Puerarin via Transforming Growth Factor (TGF-β1)
por: Hu, Xiaoming, et al.
Publicado: (2019)

Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”
por: Xie, Qiang, et al.
Publicado: (2016)

Hepatic Steatosis Index Is Associated with Type 1 Diabetes Complications
por: Tripolino, Cesare, et al.
Publicado: (2019)

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles
por: Luo, Cheng-Feng, et al.
Publicado: (2013)

Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: Evaluation of Hepatic Fibrosis and Steatosis Using Fibroscan
por: Tuong, Tran Thi Khanh, et al.
Publicado: (2020)

Monkfish Peptides Mitigate High Fat Diet-Induced Hepatic Steatosis in Mice
por: Ye, Jiena, et al.
Publicado: (2022)

Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats
por: Pan, Xiaoxia, et al.
Publicado: (2015)

Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism
por: McCommis, Kyle S., et al.
Publicado: (2018)

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice
por: Yang, Ling, et al.
Publicado: (2017)

Molecular Phenomics and Metagenomics of Hepatic Steatosis in Non-Diabetic Obese Women
por: Hoyles, Lesley, et al.
Publicado: (2018)

Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice
por: Krumm, Christopher S., et al.
Publicado: (2021)

Effects of Puerarin Combined with PLGA/TCP/Puerarin on Osteocalcin and Sialoprotein of Mandibular Defects
por: Guo, Ying, et al.
Publicado: (2022)

Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases
por: Zhou, Yan-Xi, et al.
Publicado: (2021)

Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
por: Li, Xueling, et al.
Publicado: (2017)

Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice
por: Chen, Xue, et al.
Publicado: (2019)

Caspase/AIF/apoptosis pathway: a new target of puerarin for diabetes mellitus therapy
por: Liang, Tao, et al.
Publicado: (2019)

IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis
por: Gao, Yinjie, et al.
Publicado: (2016)

Metabolomic Phenotype of Hepatic Steatosis and Fibrosis in Mexican Children Living with Obesity
por: Garibay-Nieto, Nayely, et al.
Publicado: (2023)

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
por: Wang, Jingyu, et al.
Publicado: (2021)

Hepatic Subcapsular Steatosis in a Diabetic CAPD Patient Receiving Intraperitoneal Insulin
por: Jang, Eun Chul, et al.
Publicado: (2006)

Nuciferine Prevents Hepatic Steatosis by Regulating Lipid Metabolismin Diabetic Rat Model
por: Ning, Qian, et al.
Publicado: (2019)

Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus
por: Mantovani, Alessandro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gqcf7maaf25507ronj9k7tms9i