The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

T follicular helper cells (T(FH)) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functio...

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Detalles Bibliográficos
Autores principales: Zou, Xueyang, Sun, Guangyu, Huo, Feifei, Chang, Lu, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051062/
https://www.ncbi.nlm.nih.gov/pubmed/30057920
http://dx.doi.org/10.1155/2018/7281453
Descripción
Sumario:T follicular helper cells (T(FH)) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of T(FH) cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of T(FH) cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of T(FH) cells and their major underlying mechanisms.

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